Examinando por Materia "Diabetes Mellitus"
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- PublicaciónAcceso abiertoAssociation between hospitalization stay and diabetic foot: an analytical cross-sectional study in three Peruvian hospitals(Medwave Estudios Limitada, 2018-11) Mejia, Christian R.; Paucar-Tito, Liz; Morales-Concha, Luz; Atamari Anahui, Noé; Rondón-Abuhadba, Evelina Andrea; Ordoñez-Linares, Marco EdmundoDiabetic foot is one of the main complications of diabetes mellitus; however, in hospitals of provinces from Perú, the relationship of this condition with hospital stay has not been calculated. Objective: To determine the association between hospitalization time and diabetic foot in three hospitals from Cusco, Perú. Methods: A cross-sectional study of secondary data analysis was conducted. We analyzed the data of patients with type 2 diabetes mellitus admitted to the internal medicine service between January and December 2016, in three tertiary hospitals in Cusco, Peru. Correlation coefficients and p-values were calculated using generalized linear models, with Gaussian family and identity function, adjusted by intervening variables. Values of p < 0.05 were considered statistically significant. Results: Of the 153 patients, 14% (21) had a diabetic foot diagnosis, and their median age was 61 years (interquartile range 56 to 68). Those who had a diabetic foot had on average 20 hospitalization days. A strong association was found between a diabetic foot and the number of hospitalization days (17 days more, p = 0.003); adjusted by six variables. Those patients with a history of hypertension had more hospitalization days (10 days more, p = 0.011) and those admitted to a hospital of the Ministry of Health, had fewer hospitalization days (10 days less, p = 0.032). Conclusion: The group of patients with diabetic foot had a longer hospitalization time. The longer hospitalization time could be due to complications of the disease or difficulties in management.
- PublicaciónSólo datosAssociation between serum vitamin B12 levels and metabolic syndrome in a euthyroid population(Diabetes India, 2018-05) Guarnizo-Poma, Mirella; Urrunaga-Pastor, Diego; Montero-Suyo, Cory; Lazaro-Alcantara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Benites Zapata, Vicente A.Aims: To determine the association between serum levels of vitamin B12 and metabolic syndrome (MetS) in a population of euthyroid adults. Materials and methods: We carried out an analytical cross-sectional study in euthyroid adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were divided into tertiles (low, intermediate and high) according to their serum vitamin B12 values. MetS was defined when three or more metabolic criteria were met by the participants. We elaborated crude and adjusted Poisson regression models to evaluate the association between the serum vitamin B12 tertiles and the presence of MetS. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI).
- PublicaciónSólo datosAssociation between vitamin D deficiency and insulin resistance markers in euthyroid non-diabetic individuals(Insulin Resistance and Metabolic Syndrome Research Group, 2019) Urrunaga Pastor, Diego; Guarnizo Poma, Mirella; Macollunco Flores, Pilar; Lazaro Alcantara, Herbert; Paico Palacios, Socorro; Pantoja Torres, Betzi; Benites Zapata, Vicente A.Aim: To evaluate the association between vitamin D deficiency and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in euthyroid non-diabetic individuals. Materials and methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012e2016 period. Participants were categorized in two groups according to their serum vitamin D levels: normal vitamin D levels (serum vitamin D values 20 ng/dL) and vitamin D deficiency (serum vitamin D values < 20 ng/dL). IR was defined as a Homeostasis Model Assessment (HOMA-IR) value 3.8 and hyperinsulinemia after OGTT was defined as a serum insulin value 80mU/mL after 120min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between serum vitamin D levels and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 204 participants, the average age was 38.5 ± 10.6 (SD) years, 40 (19.6%) were males and the vitamin D median was 25.0 (IQR: 19.0e33.3) ng/dL. The prevalence of vitamin D deficiency, IR and hyperinsulinemia after OGTT was 29.4% (n ¼ 60), 29.9% (n ¼ 61) and 25.0% (n ¼ 51). In the adjusted Poisson regression models, the prevalence of hyperinsulinemia after OGTT was higher among the vitamin D deficient group (aPR¼1.75; 95%CI: 1.06e2.90); however, we did not find statistically significant association between vitamin D deficiency and IR (aPR¼0.99; 95%CI: 0.61e1.63). Conclusions: We found an association between vitamin D deficiency and hyperinsulinemia after OGTT in euthyroid people with no T2DM.Our findings are consistent with previous reports; providing evidence that serum vitamin D deficiency could be an IR marker.
- PublicaciónAcceso abiertoFactores asociados al síndrome metabólico según definiciones de FID y ATP III en comedores populares en Cercado de Lima en el 2015(Universidad San Ignacio de Loyola, 2017) Adams Ubaldo, Karen Judith; Alvarado Ortiz Ureta, Carlos EduardoEl síndrome metabólico (SM) es un grave problema de salud pública en nuestro país y se explica como un conjunto de alteraciones metabólicas determinadas por los cambios en el estilo de vida y los hábitos de alimentación. Objetivo: Identificar los factores asociados para desarrollar síndrome metabólico según las definiciones de FID y ATP III en adultos usuarios de los comedores populares en Cercado de Lima. Materiales y métodos: se realizó un estudio observacional, transversal, prospectivo con una población de 374 individuos de 20 a 59 años usuarios de comedores populares en Cercado de Lima. En la determinación del SM se utilizaron los criterios propuestos por la Federación Internacional de Diabetes (FID) y el Panel de expertos en detección, evaluación y tratamiento del colesterol alto en sangre en adultos (ATP III). Resultados: La prevalencia de los componentes del SM estudiados según FID en la población fue: obesidad abdominal 81%, C-HDL disminuido 49%, hipertrigliceridemia 44,4%, hipertensión arterial 25,6% e hiperglicemia 16%. Según la definición de ATP III, la prevalencia de obesidad abdominal alcanzó el 52,7%, el C-HDL disminuido 49%, hipertrigliceridemia el 4,.4%, la hipertensión arterial el 23% y la hiperglicemia el 11%. La prevalencia del SM en la población fue de 40,1% (FID), las mujeres 76,3% y los varones 23,7%, con diferencias significativas (p < 0,01) y 30,7% se obtuvo para la prevalencia del SM según ATP III. Las combinaciones según criterios en ambas definiciones resultaron: Obesidad central - Hipertrigliceridemia - colesterol HDL disminuido.
- PublicaciónSólo datosHigh triglycerides to HDL-cholesterol ratio is associated with insulin resistance in normal-weight healthy adults(Elsevier B.V., 2019-02) Pantoja-Torres, Betzi; Toro Huamanchumo, Carlos J.; Urrunaga Pastor, Diego; Guarnizo Poma, Mirella; Lázaro Alcántara, Herbert; Paico Palacios, Socorro; Del Carmen Ranilla Seguin, Vitalia; Benites Zapata, Vicente A.Aim: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. Methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8% (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n = 29) and 17.0% (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95%CI: 1.80–5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95%CI: 1.20–4.63). Conclusions: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus. © 2018 Diabetes India
- PublicaciónSólo datosHigh waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women(Elsevier Ltd, 2019-02) Benites Zapata, Vicente A.; Toro Huamanchumo, Carlos J.; Urrunaga-Pastor, Diego; Guarnizo-Poma, Mirella; Lázaro-Alcántara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Ranilla-Seguin, Vitalia Del CarmenAim: To assess the association between high waist-to-hip ratio (WHR) levels and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of normal-weight women. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic women, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high WHR levels, IR or hyperinsulinemia after OGTT. We considered WHR values > 0.85 as high levels. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value > 2.39 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high WHR levels and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI).
- PublicaciónAcceso abiertoMortalidad atribuida a diabetes mellitus registrada en el Ministerio de Salud de Perú, 2005-2014(Pan Amer Health Organization, 2018-05) Atamari-Anahui, Noe; Suker Ccorahua-Rios, Maycol; Taype Rondán, Álvaro; Mejia, Christian R.Objective. To estimate the mortality attributable to diabetes mellitus (DM) as recorded by Peru’s Ministry of Health and its association with the human development index (HDI). Methods. This was an ecological study based on a secondary analysis of death records belonging to the Ministry of Health for the period from 2005 to 2014. A death was considered attributable to DM if the underlying cause of death given in the death record was DM. Mortality attributable to DM has been presented descriptively and in terms of geospatial analyses, and Spearman’s rho was used to test for an association between the difference in the mortality attributable to DM (between 2005-2006 and 2013-2014) and the HDI in Peru’s various departments.
- PublicaciónAcceso abiertoProducción científica en diabetes en Perú: Un estudio bibliométrico(Sociedad Chilena de Nutrición, Bromatología y Toxicología, 2017-06) Taype Rondán, Álvaro; Huapaya-Huertas, Oscar; Bendezu-Quispe, Guido; Pacheco Mendoza, Josmel; Bryce-Alberti, MayteObjetivo: describir la producción científica en diabetes en Perú entre 1996 y 2015. Métodos: Estudio bibliométrico. Se identificaron publicaciones científicas sobre diabetes que tuvieran algún autor con filiación peruana, en las bases de datos Web of Science Core Collection (WoS) y Scopus, entre 1996 y 2015. Se extrajeron manualmente las variables de interés. Se presentaron los resultados descriptivos y las redes de colaboración. Resultados: Se encontraron 81 publicaciones, el 75,3% fueron artículos originales, de las cuales ninguno evaluó intervenciones en salud pública y 60,7% recibieron financiamiento extranjero. El 55,6% tuvieron algún autor afiliado a la Universidad Peruana Cayetano Heredia (UPCH), y el 65,4% algún autor extranjero. Se puedo distinguir cinco conglomerados de redes de colaboración internacional, todos con participación de la UPCH.
- PublicaciónSólo datosTriglycerides and glucose index as an insulin resistance marker in a sample of healthy adults(Elsevier B.V., 2019-02) Toro Huamanchumo, Carlos J.; Urrunaga Pastor, Diego; Guarnizo Poma, Mirella; Lázaro Alcántara, Herbert; Paico Palacios, Socorro; Pantoja Torres, Betzi; Ranilla-Seguin, Vitalia Del Carmen; Benites Zapata, Vicente A.Aim: To assess the association between elevated triglycerides/glucose index (TGI) and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of healthy adults. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were categorized in two groups according to the presence or absence of elevated TGI, IR or hyperinsulinemia after OGTT. A TGI value ≥ 8.65 was considered as elevated. We defined IR as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between elevated TGI and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 118 individuals, the average age was 37.5 ± 11.3 years, 21 (17.8%) were males and the median BMI was 22.7 ± 1.6 kg/m2. The prevalence of elevated TGI was 25.4% (n=30) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n=29) and 17.0% (n=20) respectively. In the adjusted model, elevated TGI was associated with both IR (aPR=6.36; 95%CI: 3.41–11.86) and hyperinsulinemia after OGTT (aPR=4.19; 95%CI: 1.81–9.70). Conclusions: We found that elevated TGI was associated with both IR markers in a sample of euthyroid adults without T2DM and with a normal BMI. The simplicity of the TGI calculation makes it the first-choice alternative when the hyperinsulinemic-euglycemic clamp or HOMA-IR are not available. © 2018 Diabetes India