Publicación:
ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus

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dc.citation.epage457
dc.citation.issue4
dc.citation.spage454
dc.citation.volume39
dc.contributor.authorHerrera Añazco, Percy
dc.contributor.authorVelásquez-Castillo, Percy
dc.contributor.authorPacheco Mendoza, Josmel
dc.contributor.authorValenzuela-Rodríguez, Germán
dc.contributor.authorAsato-Higa, Carmen
dc.date.accessioned2019-02-12T20:25:35Z
dc.date.available2019-02-12T20:25:35Z
dc.date.issued2017-10
dc.description.abstractThe pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule. 67% of the glomeruli had fibroepithelial crescents. Moreover, the interstitial space had a moderate lymphomononuclear infiltration and mild fibrosis. In the arterioles, there were walls thickened by subintimal sclerosis. Direct immunofluorescence detected limited IgM and C3 deposits in capillary loops and negative mensangium for IgG, IgA and C1q. A therapy using corticosteroids and intravenous cyclophosphamide was initiated with stable evolution. PICGN associated with SLE is a rare pathology with clinical presentation, varied evolution and without a standard medical treatment.es_ES
dc.description.peer-reviewRevisado por pareses_ES
dc.formatapplication/pdfes_ES
dc.identifier.citationHerrera-Añazco, P., Velásquez-Castillo, P., Pacheco-Mendoza, J., Valenzuela-Rodriguez, G., & Asato-Higa, C. (2017). ANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus. Brazilian Journal of Nephrology, 39(4), 454-457.en
dc.identifier.doi10.5935/0101-2800.20170079
dc.identifier.journalJornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologiaes_ES
dc.identifier.urihttps://hdl.handle.net/20.500.14005/8562
dc.identifier.urihttp://dx.doi.org/10.5935/0101-2800.20170079
dc.identifier.urihttp://bjn.org.br/details/1994/en-US/anca-positive-pauci-immune-crescentic-glomerulonephritis-in-a-patient-with-systemic-lupus-erythematosus
dc.language.isospaes_ES
dc.publisherSociedade Brasileira de Nefrologiaes_ES
dc.relation.ispartofJornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.sourceUniversidad San Ignacio de Loyolaes_ES
dc.sourceRepositorio Institucional - USILes_ES
dc.subjectAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitisen
dc.subjectGlomerulonephritisen
dc.subjectLupus Erythematosus, Systemicen
dc.titleANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosuses_ES
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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