The aim of the study was to compare the quality of life in adults with intellectual disabilities who participate in occupational or employment-related activities in the city of Lima. The sample was comprised of 71 people, 40 males (56.3%) and 31 females (43.7%); 35 of them (49.3%) participate in occupational activities and 36 of them (50.7%) participate in activities that involve employment-related activities. The Integral Scale of Quality of Life was administered to primary caregivers of these individuals. We found that people who are involved in employment-related activities have better indicators of quality of life in the dimensions of Social Inclusion, Work Well-Being and Emotional and Physical Well-Being than the other participants. Self-determination and Well-Being Material showed no significant differences between these groups. It is concluded that persons participating in employment-related activities present a better quality of life in comparison with persons involved in occupational activities.