Publicación:
Association between vitamin D deficiency and insulin resistance markers in euthyroid non-diabetic individuals

Vista sencilla de ítem
dc.citation.issue1
dc.citation.volume13
dc.contributor.authorUrrunaga Pastor, Diego
dc.contributor.authorGuarnizo Poma, Mirella
dc.contributor.authorMacollunco Flores, Pilar
dc.contributor.authorLazaro Alcantara, Herbert
dc.contributor.authorPaico Palacios, Socorro
dc.contributor.authorPantoja Torres, Betzi
dc.contributor.authorBenites Zapata, Vicente A.
dc.date.accessioned2018-10-11T22:04:59Z
dc.date.available2018-10-11T22:04:59Z
dc.date.issued2019
dc.description.abstractAim: To evaluate the association between vitamin D deficiency and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in euthyroid non-diabetic individuals. Materials and methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012e2016 period. Participants were categorized in two groups according to their serum vitamin D levels: normal vitamin D levels (serum vitamin D values 20 ng/dL) and vitamin D deficiency (serum vitamin D values < 20 ng/dL). IR was defined as a Homeostasis Model Assessment (HOMA-IR) value 3.8 and hyperinsulinemia after OGTT was defined as a serum insulin value 80mU/mL after 120min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between serum vitamin D levels and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 204 participants, the average age was 38.5 ± 10.6 (SD) years, 40 (19.6%) were males and the vitamin D median was 25.0 (IQR: 19.0e33.3) ng/dL. The prevalence of vitamin D deficiency, IR and hyperinsulinemia after OGTT was 29.4% (n ¼ 60), 29.9% (n ¼ 61) and 25.0% (n ¼ 51). In the adjusted Poisson regression models, the prevalence of hyperinsulinemia after OGTT was higher among the vitamin D deficient group (aPR¼1.75; 95%CI: 1.06e2.90); however, we did not find statistically significant association between vitamin D deficiency and IR (aPR¼0.99; 95%CI: 0.61e1.63). Conclusions: We found an association between vitamin D deficiency and hyperinsulinemia after OGTT in euthyroid people with no T2DM.Our findings are consistent with previous reports; providing evidence that serum vitamin D deficiency could be an IR marker.en
dc.description.peer-reviewRevisado por pareses_ES
dc.formatapplication/pdfes_ES
dc.identifier.citationUrrunaga-Pastor, D., Guarnizo-Poma, M., Macollunco-Flores, P., Lazaro-Alcantara, H., Paico-Palacios, S., Pantoja-Torres, B., Benites-Zapata, V. A. & Metabolic Syndrome Research Group. (2019). Association between vitamin D deficiency and insulin resistance markers in euthyroid non-diabetic individuals. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13(1), 258-263.en
dc.identifier.issn1871-4021
dc.identifier.journalElsevieres_ES
dc.identifier.journalDiabetes & Metabolic Syndrome: Clinical Research & Reviewsen
dc.identifier.urihttps://hdl.handle.net/20.500.14005/3867
dc.identifier.urihttps://doi.org/10.1016/j.dsx.2018.09.008
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1871402118303680
dc.language.isoenges_ES
dc.publisherInsulin Resistance and Metabolic Syndrome Research Groupes_ES
dc.relation.ispartofDiabetes & Metabolic Syndrome: Clinical Research & Reviewsen
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_ES
dc.sourceUniversidad San Ignacio de Loyolaes_ES
dc.sourceRepositorio Institucional - USILes_ES
dc.subjectResistencia a la Insulinaes_ES
dc.subjectVitamina Des_ES
dc.subjectGlucemiaes_ES
dc.subject.meshDiabetes Mellitusen
dc.subject.meshVitamin D Deficiencyen
dc.subject.meshInsulin Resistanceen
dc.titleAssociation between vitamin D deficiency and insulin resistance markers in euthyroid non-diabetic individualses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dspace.entity.typePublication
Archivos
Colecciones
Artículos Académico-científicos