Examinando por Materia "Sexual Dysfunction, Physiological"
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- PublicaciónAcceso abiertoAssociation between Menopausal Status and Risk of Sexual Dysfunction in Sexually Active Women Infected With HIV Infection: Analysis of a Peruvian Series(World Association for Sexual Health, 2019-10-12) Mezones Holguin, EdwardBackground: Highly active antiretroviral therapy (HAART) has contributed to increase survival in women infected with human immunodeficiency virus (HIV) infection. Thus, an important proportion of these women are able to reach mid-age. However, current available information regarding different outcomes of interest during the climacteric stage in this type of patients is limited. Objective: To evaluate the association between menopausal status and risk of sexual dysfunction (RSD) in sexually active mid-aged women infected with HIV controlled by clinical and demographic variables. Methods: We carried out a secondary analysis to a cross-sectional study conducted in Lima, Peru. We evaluated 221 sexually active women infected with HIV (40 to 59 years). Menopausal status was classified according to Stages of Reproductive Aging Workshop criteria in premenopausal, perimenopausal, and postmenopausal women. RSD was assessed with the “Female Sexual Function Index”. In addition, other socio-demographic and clinical variables were measured such as age, HAART scheme, time of disease and comorbidities. We performed generalized linear models LOGIT using a binomial model with robust variance to estimate 95% CI, Crude Odds ratio (ORc) and Adjusted Odds ratio (ORa) according to levels of epidemiology study. Results: The mean age of women studied was 47.0 ± 5.2 years, including 25.3% premenopausal and 48.9% postmenopausal women. Frequencies of RSD were 64.3%, 53.6% and 75% for all premenopausal and menopausal women, respectively. Compared to premenopausal women, postmenopausal women were associated with RSD at crude (ORc ¼ 2.60, 95%CI ¼ 1.31–5.2, p ¼ 0.006) and adjusted (ORa ¼ 2.73, 95% CI ¼ 1.31–5.67, p¼0.007) models. Conclusion: Our findings suggest that the postmenopausal status in sexually active women infected with HIV showed higher odd ratios for RSD. The study of the sexual sphere should be included in the comprehensive evaluation of middle-age women infected with HIV. Further research is warranted in this regard.
- PublicaciónAcceso abiertoCáncer de mama y disfunción sexual femenina: análisis en una muestra de mujeres peruanas adultas(World Association for Sexual Health, 2019-10-13) Pasapera-Rivera, Manuel; Zeta-Solis, Ludwing; Mendoza-de-Lama, Gastón; Mezones Holguin, EdwardIntroduction: Sexuality is a complex area in women, especially in those who have been diagnosed with breast cancer (BC). Objective: To evaluate whether there is an association between breast cancer (BC) and sexual dysfunction (SD) in adult women in a national reference hospital of Social Security in Peru. Method and sample: We carried out an analysis in 167 women under 60 years of age, which were divided into two groups: with BC (after mastectomy and without mastectomy), and without cancer. We used the validation of the Spanish version of the Female Sexual Dysfunction Index. We made a comparison among women with BC and without cancer (A). Additionally, we carried out two exploratory comparisons: among women with BC after mastectomy and without mastectomy (B); and another among women without BC, with BC after mastectomy, and with BC without mastectomy (C). We estimated crude prevalence ratios (cPR) and adjusted prevalence ratios (aPR) with 95% CI using generalized lineal Poisson regression models with a non-parametric bias-corrected and accelerated boostrap. Results: The frequencies of SD were 95,7%; 43,8% and 35,1% in women with BC after mastectomy; with BC without undergoing mastectomy and without cancer, respectively. In A, it was observed that women with BC presented a higher probability of SD than those without cancer (cPR:1.86; CI95%:1,27–2,72/ aPR:1,51; CI95%:1,06–2,15). In B, it was evidenced that, among women with BC, those after mastectomy had a higher probability of SD (cPR:2,19; CI95%: 1,63–2,92/ aPR:1,62; CI95%: 1,26–2,08). In C, a higher probability of SD was identified in women with BC after mastectomy versus women without cancer (cPR 2,73; CI 95%: 1,88–3,94/ aPR:1,93; CI 95%: 1,32–2,80). Conclusion and recommendation: The frequency of SD is higher in women with breast cancer and, in this group, the probability is higher in women with mastectomy antecedents. In this group of women, the sexual sphere should be explored in the clinical practice.
- PublicaciónAcceso abiertoEficacia y seguridad de la dapoxetina en el tratamiento de la eyaculación precoz: una sinopsis de revisiones sistemáticas(World Association for Sexual Health, 2019-10-13) Mezones Holguin, EdwardIntroduction: Premature ejaculation (PE) is a frequent condition for which there are several pharmacological therapies at present. Objective: To evaluate the available scientific evidence regarding the efficacy and safety of Dapoxetine in the treatment of PE. Methods and objective: We developed a synopsis of systematic reviews (SR) of randomized clinical trials (RCTs) that included male patients with the diagnosis of PE. We carried out a primary search without any language restriction in Pubmed-Medline, WOS, EMBASE, SCOPUS and Cochrane Library until March, 2019. R-AMSTAR was used for quality assessment. Selection, quality assessment and extraction were carried out blindly and independently by two authors and resolved by discussion of referral to a third author. Results: We identified 16 SR: five network metaanalyses (NMA), ten traditional meta-analyses (TMA), and a SR without meta-analysis. In the NMA, Dapoxetine was compared with other pharmacological and non-pharmacological therapies such as placebo; in two of them, it was concluded that the use of Dapoxetine, at a dose of 30 mg, was as effective as other alternatives, but with a better safety profile, mainly when it was used as a needed therapy. In the seven (TMA), in which Dapoxetine was compared with placebo, it was reported that, at different doses (60mg or 30 mg), the effect of Dapoxetine was higher in the latent period of intravaginal ejaculation. In the three remaining meta-analyses, other medicines were included as comparators, where Dapoxetine demonstrated to have good efficacy profile and to be one of the highest safety profiles. A potential advantage of Dapoxetine identified in SR is its use as needed therapy. Conclusion & recommendation: The evidence discussed shows that dapoxetine is efficacious and has a good safety profile in the treatment of PE in adults. This evidence should be considered for the implementation of clinical practical guides on PE and its management update.
- PublicaciónSólo datosSexual dysfunction was associated to depressed mood in mid-aged women from Paraguay(Elsevier B.V., 2019-06) Sánchez Zarza, Sandra; Mezones Holguin, Edward; Soto Becerra, Percy; Pérez López, Faustino R.; Gavilanes, Antonio W.D.; Chedraui, PeterReports indicate that depressive symptoms may affect sexuality of mid-aged women and vice versa sexual problems tend to aggravate depression. Despite this, information addressing this association drawn from mid-aged Paraguayan women is scarce. This was a cross-sectional study in which sexually active women from Asunción (Paraguay, aged 40 to 60 years) were surveyed with the 6 ítem Female sexual Function Index (FSFI-6), the 10-ítem Center for Epidemiological Studies Depression Scale (CESD-10) and a general questionnaire containing personal and partner data.