Examinando por Materia "Insulin Resistance"
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- PublicaciónSólo datosAssociation between vitamin D deficiency and insulin resistance markers in euthyroid non-diabetic individuals(Insulin Resistance and Metabolic Syndrome Research Group, 2019) Urrunaga Pastor, Diego; Guarnizo Poma, Mirella; Macollunco Flores, Pilar; Lazaro Alcantara, Herbert; Paico Palacios, Socorro; Pantoja Torres, Betzi; Benites Zapata, Vicente A.Aim: To evaluate the association between vitamin D deficiency and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in euthyroid non-diabetic individuals. Materials and methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012e2016 period. Participants were categorized in two groups according to their serum vitamin D levels: normal vitamin D levels (serum vitamin D values 20 ng/dL) and vitamin D deficiency (serum vitamin D values < 20 ng/dL). IR was defined as a Homeostasis Model Assessment (HOMA-IR) value 3.8 and hyperinsulinemia after OGTT was defined as a serum insulin value 80mU/mL after 120min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between serum vitamin D levels and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 204 participants, the average age was 38.5 ± 10.6 (SD) years, 40 (19.6%) were males and the vitamin D median was 25.0 (IQR: 19.0e33.3) ng/dL. The prevalence of vitamin D deficiency, IR and hyperinsulinemia after OGTT was 29.4% (n ¼ 60), 29.9% (n ¼ 61) and 25.0% (n ¼ 51). In the adjusted Poisson regression models, the prevalence of hyperinsulinemia after OGTT was higher among the vitamin D deficient group (aPR¼1.75; 95%CI: 1.06e2.90); however, we did not find statistically significant association between vitamin D deficiency and IR (aPR¼0.99; 95%CI: 0.61e1.63). Conclusions: We found an association between vitamin D deficiency and hyperinsulinemia after OGTT in euthyroid people with no T2DM.Our findings are consistent with previous reports; providing evidence that serum vitamin D deficiency could be an IR marker.
- PublicaciónSólo datosAssociation between waist circumference and waist-to-height ratio with insulin resistance biomarkers in normal-weight adults working in a private educational institution(Elsevier Ltd, 2019-05) Urrunaga Pastor, Diego; De La Fuente-Carmelino, Luciana; Toro Huamanchumo, Carlos J.; Pérez-Zavala, Miriam; Benites Zapata, Vicente A.Aim: To assess the association between elevated waist circumference (WC)and high waist-to-height ratio (WHtR)with insulin resistance biomarkers. Methods: We conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC ≥ 90 in male participants and WC ≥ 80 in adult women as elevated, and values of WHtR≥0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C)ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio ≥ 3 as high and TGI values ≥ 8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR)with their respective 95% confidence intervals (95%CI). Results: We analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2% (n = 61)and 33.2% (n = 118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8% (n = 88)and 12.7% (n = 45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR = 3.61; 95%CI: 1.59–8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR = 2.54; 95%CI:1.08–5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR = 1.54; 95%CI: 0.95–2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR = 1.87; 95%CI: 1.00–3.50).