Examinando por Autor "Benites Zapata, Vicente A."
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- PublicaciónSólo datosAssociation between serum vitamin B12 levels and metabolic syndrome in a euthyroid population(Diabetes India, 2018-05) Guarnizo-Poma, Mirella; Urrunaga-Pastor, Diego; Montero-Suyo, Cory; Lazaro-Alcantara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Benites Zapata, Vicente A.Aims: To determine the association between serum levels of vitamin B12 and metabolic syndrome (MetS) in a population of euthyroid adults. Materials and methods: We carried out an analytical cross-sectional study in euthyroid adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were divided into tertiles (low, intermediate and high) according to their serum vitamin B12 values. MetS was defined when three or more metabolic criteria were met by the participants. We elaborated crude and adjusted Poisson regression models to evaluate the association between the serum vitamin B12 tertiles and the presence of MetS. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI).
- PublicaciónSólo datosAssociation between vitamin D deficiency and insulin resistance markers in euthyroid non-diabetic individuals(Insulin Resistance and Metabolic Syndrome Research Group, 2019) Urrunaga Pastor, Diego; Guarnizo Poma, Mirella; Macollunco Flores, Pilar; Lazaro Alcantara, Herbert; Paico Palacios, Socorro; Pantoja Torres, Betzi; Benites Zapata, Vicente A.Aim: To evaluate the association between vitamin D deficiency and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in euthyroid non-diabetic individuals. Materials and methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults of both sexes, who attended the outpatient service of a private clinic in Lima-Peru during the 2012e2016 period. Participants were categorized in two groups according to their serum vitamin D levels: normal vitamin D levels (serum vitamin D values 20 ng/dL) and vitamin D deficiency (serum vitamin D values < 20 ng/dL). IR was defined as a Homeostasis Model Assessment (HOMA-IR) value 3.8 and hyperinsulinemia after OGTT was defined as a serum insulin value 80mU/mL after 120min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between serum vitamin D levels and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 204 participants, the average age was 38.5 ± 10.6 (SD) years, 40 (19.6%) were males and the vitamin D median was 25.0 (IQR: 19.0e33.3) ng/dL. The prevalence of vitamin D deficiency, IR and hyperinsulinemia after OGTT was 29.4% (n ¼ 60), 29.9% (n ¼ 61) and 25.0% (n ¼ 51). In the adjusted Poisson regression models, the prevalence of hyperinsulinemia after OGTT was higher among the vitamin D deficient group (aPR¼1.75; 95%CI: 1.06e2.90); however, we did not find statistically significant association between vitamin D deficiency and IR (aPR¼0.99; 95%CI: 0.61e1.63). Conclusions: We found an association between vitamin D deficiency and hyperinsulinemia after OGTT in euthyroid people with no T2DM.Our findings are consistent with previous reports; providing evidence that serum vitamin D deficiency could be an IR marker.
- PublicaciónSólo datosAssociation between waist circumference and waist-to-height ratio with insulin resistance biomarkers in normal-weight adults working in a private educational institution(Elsevier Ltd, 2019-05) Urrunaga Pastor, Diego; De La Fuente-Carmelino, Luciana; Toro Huamanchumo, Carlos J.; Pérez-Zavala, Miriam; Benites Zapata, Vicente A.Aim: To assess the association between elevated waist circumference (WC)and high waist-to-height ratio (WHtR)with insulin resistance biomarkers. Methods: We conducted an analytical cross-sectional study in normal-weight adults. Participants were divided in two groups according to WC or WHtR levels. We considered values of WC ≥ 90 in male participants and WC ≥ 80 in adult women as elevated, and values of WHtR≥0.50 as high, for both genders. Our outcomes were high triglycerides to HDL-cholesterol (TG/HDL-C)ratio and elevated triglycerides and glucose index (TGI). We considered values of TG/HDL-C ratio ≥ 3 as high and TGI values ≥ 8.37 as elevated. We elaborated crude and adjusted Poisson generalized linear models to evaluate the proposed associations and explored the gender interaction using stratified models. We reported the prevalence ratio (PR)with their respective 95% confidence intervals (95%CI). Results: We analyzed 355 participants. The prevalence of elevated WC and high WHtR was 17.2% (n = 61)and 33.2% (n = 118), respectively, while the prevalence of high TG/HDL-C ratio and elevated TGI was 24.8% (n = 88)and 12.7% (n = 45), respectively. In the adjusted regression model, elevated WC was associated with high TG/HDL-C ratio only in female participants (aPR = 3.61; 95%CI: 1.59–8.20). Similarly, high WHtR was associated with high TG/HDL-C ratio in women (aPR = 2.54; 95%CI:1.08–5.97). We found an association with statistically marginal significance between elevated WC and elevated TGI in women (aPR = 1.54; 95%CI: 0.95–2.50); as well as for the association between high WHtR and elevated TGI in male participants (aPR = 1.87; 95%CI: 1.00–3.50).
- PublicaciónSólo datosHigh triglycerides to HDL-cholesterol ratio is associated with insulin resistance in normal-weight healthy adults(Elsevier B.V., 2019-02) Pantoja-Torres, Betzi; Toro Huamanchumo, Carlos J.; Urrunaga Pastor, Diego; Guarnizo Poma, Mirella; Lázaro Alcántara, Herbert; Paico Palacios, Socorro; Del Carmen Ranilla Seguin, Vitalia; Benites Zapata, Vicente A.Aim: To evaluate the association between high triglyceride/HDL-cholesterol (TG/HDL-C) ratio and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in normal-weight healthy adults. Methods: We carried out an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high TG/HDL-C ratio, IR or hyperinsulinemia after OGTT. TG/HDL-C ratio values ≥ 3 were considered as high. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high TG/HDL-C ratio and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed the data of 118 individuals. Prevalence of high TG/HDL-C ratio was 17.8% (n = 21) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n = 29) and 17.0% (n = 20), respectively. TG/HDL-C-ratio values were positively correlated with HOMA-IR (r = 0.498; p < 0.01) and serum insulin after OGTT (r = 0.326; p < 0.001). In the adjusted model, high TG/HDL-C ratio was associated with both IR (aPR = 3.16; 95%CI: 1.80–5.77) and hyperinsulinemia after OGTT (aPR = 2.36; 95%CI: 1.20–4.63). Conclusions: High TG/HDL-C ratio was associated with both IR markers used in our study, appearing to be a clinically useful tool to assess IR in euthyroid normal-weight adults without type 2 diabetes mellitus. © 2018 Diabetes India
- PublicaciónSólo datosHigh waist-to-hip ratio levels are associated with insulin resistance markers in normal-weight women(Elsevier Ltd, 2019-02) Benites Zapata, Vicente A.; Toro Huamanchumo, Carlos J.; Urrunaga-Pastor, Diego; Guarnizo-Poma, Mirella; Lázaro-Alcántara, Herbert; Paico-Palacios, Socorro; Pantoja-Torres, Betzi; Ranilla-Seguin, Vitalia Del CarmenAim: To assess the association between high waist-to-hip ratio (WHR) levels and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of normal-weight women. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic women, who attended the outpatient service of a private clinic in Lima-Peru from 2012 to 2016. Participants were divided in two groups according to the presence or absence of high WHR levels, IR or hyperinsulinemia after OGTT. We considered WHR values > 0.85 as high levels. IR was defined as a Homeostasis Model Assessment (HOMA-IR) value > 2.39 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between high WHR levels and IR or hyperinsulinemia after OGTT and reported the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI).
- PublicaciónAcceso abiertoOcular Exposure to Particulate Matter and Development of Pterygium: A Case-Control Study(NIOC Health Organization, 2018-10) Alberto Ramirez, Carlos; Pérez-Martinot, Manuel; Gil-Huayanay, Delia; Urrunaga Pastor, Diego; Benites Zapata, Vicente A.Background: Formation of pterygium has been mainly attributed to exposure to the ultraviolet (UV) radiation. Other factors such as dry weather, wind exposure and microtrauma with dust particles, have been linked to development of pterygium. Objective: To determine the association between ocular exposure to particulate matter and development of pterygium. Methods: This case-control study was conducted in a company dedicated to the production and marketing of toilets. We included a total of 90 cases identified in November 2013 and 184 controls. The diagnosis of pterygium was based on clinical examination. Variables studied included age and job tenure of the participants. Logistic regression analysis was used to assess the effect of exposure on developing pterygium. Results: All study participants were male. The mean age of the cases and controls was 39.9 (SD 9.5) and 37.8 (SD 7.3) years, respectively. 115 (42%) of the participants had a job tenure of 5–8 years. The percentages of cases and controls exposed to particulate matter were 31.1% (n=28) and 30.4% (n=56), respectively (OR 1.08, 95% CI 0.61 to 1.91). Conclusion: We could not observe any association between ocular exposure to particulate matter and development of pterygium.
- PublicaciónSólo datosSíndrome de Sturge-Weber tipo 2(Ediciones Doyma, S.L., 2019-05) Guerreros Espino, Camila; Collazos Huamán, Lucero; Valdivieso Herrera, Marco Antonio Josué; Benites Zapata, Vicente A.
- PublicaciónSólo datosTriglycerides and glucose index as an insulin resistance marker in a sample of healthy adults(Elsevier B.V., 2019-02) Toro Huamanchumo, Carlos J.; Urrunaga Pastor, Diego; Guarnizo Poma, Mirella; Lázaro Alcántara, Herbert; Paico Palacios, Socorro; Pantoja Torres, Betzi; Ranilla-Seguin, Vitalia Del Carmen; Benites Zapata, Vicente A.Aim: To assess the association between elevated triglycerides/glucose index (TGI) and insulin resistance (IR) or hyperinsulinemia after oral glucose tolerance test (OGTT) in a sample of healthy adults. Methods: We conducted an analytical cross-sectional study in euthyroid non-diabetic adults, who attended the outpatient service of a private clinic in Lima-Peru during the 2012–2016 period. Participants were categorized in two groups according to the presence or absence of elevated TGI, IR or hyperinsulinemia after OGTT. A TGI value ≥ 8.65 was considered as elevated. We defined IR as a Homeostasis Model Assessment (HOMA-IR) value ≥ 2.28 and hyperinsulinemia after OGTT as a serum insulin value ≥ 80μU/mL after 120 min of 75-g glucose intake. We elaborated crude and adjusted Poisson regression models to assess the association between elevated TGI and IR or hyperinsulinemia after OGTT. The reported association measure was the prevalence ratio (PR) with their respective 95% confidence intervals (95%CI). Results: We analyzed 118 individuals, the average age was 37.5 ± 11.3 years, 21 (17.8%) were males and the median BMI was 22.7 ± 1.6 kg/m2. The prevalence of elevated TGI was 25.4% (n=30) while the prevalence of IR and hyperinsulinemia after OGTT was 24.6% (n=29) and 17.0% (n=20) respectively. In the adjusted model, elevated TGI was associated with both IR (aPR=6.36; 95%CI: 3.41–11.86) and hyperinsulinemia after OGTT (aPR=4.19; 95%CI: 1.81–9.70). Conclusions: We found that elevated TGI was associated with both IR markers in a sample of euthyroid adults without T2DM and with a normal BMI. The simplicity of the TGI calculation makes it the first-choice alternative when the hyperinsulinemic-euglycemic clamp or HOMA-IR are not available. © 2018 Diabetes India