Examinando por Materia "Lupus Erythematosus, Systemic"
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- PublicaciónAcceso abiertoANCA-Positive pauci-immune crescentic glomerulonephritis in a patient with systemic lupus erythematosus(Sociedade Brasileira de Nefrologia, 2017-10) Herrera Añazco, Percy; Velásquez-Castillo, Percy; Pacheco Mendoza, Josmel; Valenzuela-Rodríguez, Germán; Asato-Higa, CarmenThe pauci-immune crescentic glomerulonephritis (PICGN) is generally associated with small-vessel vasculitis with a few reported cases associated with other autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We present the case of a female 34-year-old patient with acute kidney injury symptoms with indication for renal replacement therapy in the context of clinical SLE diagnosis. A kidney biopsy was conducted and it was found that most glomeruli showed some segmental sclerosis with synechia to the Bowman's capsule. 67% of the glomeruli had fibroepithelial crescents. Moreover, the interstitial space had a moderate lymphomononuclear infiltration and mild fibrosis. In the arterioles, there were walls thickened by subintimal sclerosis. Direct immunofluorescence detected limited IgM and C3 deposits in capillary loops and negative mensangium for IgG, IgA and C1q. A therapy using corticosteroids and intravenous cyclophosphamide was initiated with stable evolution. PICGN associated with SLE is a rare pathology with clinical presentation, varied evolution and without a standard medical treatment.
- PublicaciónAcceso abiertoAssociation between self-efficacy and health-related quality of life in patients with systemic lupus erythematosus(BMJ Journals, 2019-06) Zeña Huancas, Paola Alejandra; Reategui Sokolova, Cristina; Gamboa Cardenas, Rocio; Medina Chinchon, Mariela; Zevallos Miranda, Francisco; Pimentel Quiroz, Victor; Elera Fitzcarrald, Claudia; Alfaro Lozano, José; Pastor Asurza, Cesar; Perich Campos, Risto; Rodriguez Bellido, Zoila; Alarcon, Graciela S.; Ugarte-Gil, Manuel F.Background: Self-efficacy for managing chronic conditions assesses the confidence a person has on the ability of successfully perform specific tasks related to a chronic condition in several different situations. Self-efficacy is considered one of the most important modifiable factors in educational interventions that enhance Systemic Lupus Erythematosus (SLE) patients’ mental health status. Low disease self-efficacy is associated with SLE morbidity. Objectives: To determine the association of several domains of self-efficacy for managing chronic conditions and health-related quality of life (HRQoL) in SLE patients.
- PublicaciónAcceso abiertoPoor health-related quality of life (hrqol) and fatigue are associated with a higher work productivity impairment in systemic lupus erythematosus (sle) patients(BMJ Journals, 2019-06-15) Reategui Sokolova, Cristina; Gamboa Cárdenas, Rocío Violeta; Medina, Mariela; Zevallos Miranda, Francisco; Zeña Huancas, Paola Alejandra; Elera Fitzcarrald, Claudia; Pimentel Quiroz, Victor; Alfaro Lozano, Jose; Pastor Asurza, Cesar; Perich Campos, Risto; Rodriguez Bellido, Zoila; Alarcon, Graciela S.; Ugarte-Gil, Manuel F.Background: Because most patients with SLE are in their productive-age years, the ability to maintain a gainful employment is fundamental for both, the patient and society at large. It is thus quite important to determine the work and non-work factors that are associated with work productivity impairment in these patients. Objectives: To determine the factors associated with absenteeism (percentage of the time missed from scheduled work-time over the preceding 7 days, due to SLE), presenteeism (percentage of time from scheduled work-time where productivity was impaired while patient was at work, over the preceding 7 days, due to SLE) and overall work impairment (combination of absenteeism and presenteeism) in patients with SLE.