Examinando por Autor "Ugarte-Gil, Manuel F."
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- PublicaciónAcceso abiertoAssociation between self-efficacy and health-related quality of life in patients with systemic lupus erythematosus(BMJ Journals, 2019-06) Zeña Huancas, Paola Alejandra; Reategui Sokolova, Cristina; Gamboa Cardenas, Rocio; Medina Chinchon, Mariela; Zevallos Miranda, Francisco; Pimentel Quiroz, Victor; Elera Fitzcarrald, Claudia; Alfaro Lozano, José; Pastor Asurza, Cesar; Perich Campos, Risto; Rodriguez Bellido, Zoila; Alarcon, Graciela S.; Ugarte-Gil, Manuel F.Background: Self-efficacy for managing chronic conditions assesses the confidence a person has on the ability of successfully perform specific tasks related to a chronic condition in several different situations. Self-efficacy is considered one of the most important modifiable factors in educational interventions that enhance Systemic Lupus Erythematosus (SLE) patients’ mental health status. Low disease self-efficacy is associated with SLE morbidity. Objectives: To determine the association of several domains of self-efficacy for managing chronic conditions and health-related quality of life (HRQoL) in SLE patients.
- PublicaciónSólo datosHomocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort(Springer London, 2018-12) Zeña-Huancas, Paola A.; Iparraguirre-López, Haydee; Gamboa-Cárdenas, Rocío V.; Reategui Sokolova, Cristina; Zevallos-Miranda, Francisco; Medina-Chinchón, Mariela; Pimentel-Quiroz, Victor Román; Elera-Fitzcarrald, Claudia; Sarmiento-Velasquez, Omar; Cucho-Venegas, Jorge M.; Alfaro-Lozano, José L.; Rodríguez-Bellido, Zoila J.; Pastor-Asurza, César A.; Perich-Campos, Risto A.; Alarcón, Graciela S.; Ugarte-Gil, Manuel F.Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Univariable and multivariable Cox regression models were done to determine if homocysteine levels were predictive of damage accrual as per the SLICC Damage Index (SDI). The multivariable model was adjusted for pertinent variables (age at diagnosis, gender, socioeconomic status, disease duration, disease activity (SLEDAI), Framingham score, antimalarial and immunosuppressive drug use, average daily dose, and exposure time to prednisone (PDN)). Results: One hundred forty-five patients were included; their mean (SD) age at diagnosis was 43.70 (12.09) years, 136 (93.8%) were female, and nearly all were Mestizo. At baseline, disease duration was 7.55 (6.73) years; patients were followed for 3.54 (1.27) years. The SLEDAI was 5.60 (4.34), and the SDI 0.97 (1.35). The average daily PDN dose was 7.30 (5.78) mg/day and the time of PDN exposure was 7.36 (6.73) years. Mean homocysteine levels were 10.07 (3.71) μmol/L. The highest tertile of homocysteine levels predicted new damage accrual in the univariable and multivariable models [HR 1.78 (95% CI, 1.042–3.039); p = 0.035 and HR 2.045 (95% CI, 1.077–3.883); p = 0.029, respectively]. Increased levels (> 15 μmol/L) were found in 12 (8.3%) patients; 75 (51.7%) patients increased ≥ 1 SDI point. Conclusion: In SLE patients, homocysteine levels predicted damage accrual independently of other well-known risk factors for such occurrence. © 2018, International League of Associations for Rheumatology (ILAR).
- PublicaciónAcceso abiertoPoor health-related quality of life (hrqol) and fatigue are associated with a higher work productivity impairment in systemic lupus erythematosus (sle) patients(BMJ Journals, 2019-06-15) Reategui Sokolova, Cristina; Gamboa Cárdenas, Rocío Violeta; Medina, Mariela; Zevallos Miranda, Francisco; Zeña Huancas, Paola Alejandra; Elera Fitzcarrald, Claudia; Pimentel Quiroz, Victor; Alfaro Lozano, Jose; Pastor Asurza, Cesar; Perich Campos, Risto; Rodriguez Bellido, Zoila; Alarcon, Graciela S.; Ugarte-Gil, Manuel F.Background: Because most patients with SLE are in their productive-age years, the ability to maintain a gainful employment is fundamental for both, the patient and society at large. It is thus quite important to determine the work and non-work factors that are associated with work productivity impairment in these patients. Objectives: To determine the factors associated with absenteeism (percentage of the time missed from scheduled work-time over the preceding 7 days, due to SLE), presenteeism (percentage of time from scheduled work-time where productivity was impaired while patient was at work, over the preceding 7 days, due to SLE) and overall work impairment (combination of absenteeism and presenteeism) in patients with SLE.